Aurora inhibitor 1

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Aurora inhibitor 1 

Aurora inhibitor 1 是一种有效的 Aurora 抑制剂，抑制 Aurora A 和 Aurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。

Aurora inhibitor 1

Aurora inhibitor 1 Chemical Structure

CAS No. : 2227019-45-4

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生物活性

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].

IC50 & Target

Aurora A

4 nM (IC50)

Aurora B

13 nM (IC50)

体外研究
(In Vitro)

Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

459.57

Formula

C23H25N9S
CAS 号

2227019-45-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yu T, et al. Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403.

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