上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Dot1L-IN-1
Dot1L-IN-1是高效,选择性,结构新颖的 Dot1L 抑制剂,Ki 为2 pM。
Dot1L-IN-1 Chemical Structure
CAS No. : 2088518-50-5
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100 mg | 询价 | ||
250 mg | 询价 | ||
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生物活性 |
Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a Ki of 2 pM. |
IC50 & Target |
Ki: 2 pM (Dot1L)[1] |
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体外研究 (In Vitro) |
Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50 = 3 nM), the direct product of the Dot1Lcatalyzed reaction, as well as the activity of the HoxA9 promoter (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively[1]. Dot1L-IN-1 effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50 = 5 nM)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
646.21 |
Formula |
C32H36ClN9O2S |
CAS 号 |
2088518-50-5 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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