1,3,7-Trimethyluric acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

1,3,7-Trimethyluric acid 

1,3,7-Trimethyluric acid 是咖啡因的代谢产物。1,3,7-Trimethyluric acid与咖啡因的代谢比可用来标记 CYP3A 活性的变化。

1,3,7-Trimethyluric acid

1,3,7-Trimethyluric acid Chemical Structure

CAS No. : 5415-44-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort[1].

IC50 & Target

Human Endogenous Metabolite

 

分子量

210.19

Formula

C8H10N4O3

CAS 号

5415-44-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Y Benchekroun, et al. Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. J Chromatogr B Biomed Sci Appl. 1997 Jan 24;688(2):245-54.

    [2]. Madelé van Dyk, et al. Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. Eur J Clin Pharmacol. 2019 Sep;75(9):1211-1218.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务