PI3Kγ inhibitor 1

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PI3Kγ inhibitor 1 

PI3Kγ inhibitor 1 是一种 PI3Kδ 和 PI3Kγ 抑制剂，详细信息请参考专利文献 WO2014004470A1 中 Table 4 中的化合物 168。PI3Kγ inhibitor 1 抑制 PI3Kδ 和 PI3Kγ，IC50<100 nM。

PI3Kγ inhibitor 1

PI3Kγ inhibitor 1 Chemical Structure

CAS No. : 1172118-03-4

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生物活性

PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.

IC50 & Target[1]

PI3Kδ

100 nM (IC50)

PI3Kγ

100 nM (IC50)

PI3Kα

10 μM (IC50)

PI3Kβ

10 μM (IC50)

体外研究
(In Vitro)

In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nm, <100 <10 μm and μm, respectively. pi3kγ inhibitor 1 inhibits b cell proliferation with an ec50<100 nM.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.67

Formula

C32H26N8O2S
CAS 号

1172118-03-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.

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