Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

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Carvedilol phosphate hemihydrate (Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化,IC50 为 5 μM。Carvedilol 是一种多用途降压剂,有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂,可抑制 NLRP3 炎性体。

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

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Carvedilol phosphate hemihydrate 的其他形式现货产品:

Carvedilol (S)-Carvedilol (R)-Carvedilol

生物活性

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

IC50 & Target

β/α-1 adrenergic receptor[1]
IC50: 5 μM (lipid peroxidation)[2]
Autophagy[3]

体外研究
(In Vitro)

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC50 of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC50 of 25 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

513.48

Formula

C24H30N2O8.5P

CAS 号

610309-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.

    [2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.

    [3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

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