TH287 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TH287 hydrochloride 

TH287 hydrochloride 是一种有效的和选择性的 MTH1 抑制剂，IC50 值为 0.8 nM。TH287 hydrochloride 对 MTH1 具有高度选择性，在 100 μM 下对 MTH2，NUDT5，NUDT12，NUDT14，NUDT16，dCTPase，dUTPase 和 ITPA 没有相关抑制作用。TH287 hydrochloride 可以作为癌症研究的化学治疗剂。

TH287 hydrochloride

TH287 hydrochloride Chemical Structure

CAS No. : 1638211-05-8

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TH287 hydrochloride 的其他形式现货产品:

TH287

生物活性

TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research[1].

IC50 & Target

IC50: 0.8 nM (MTH1)[1]
体外研究
(In Vitro)

TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

305.59

Formula

C11H11Cl3N4
CAS 号

1638211-05-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

    [2]. Saleh A, et, al. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. J Pharm Biomed Anal. 2015 Feb;104:1-11.

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