IDH2R140Q-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

IDH2R140Q-IN-1 

IDH2R140Q-IN-1 (化合物 C6) 是一种有效的 IDH2R140Q 抑制剂,IC50 值为 6.1 nM。IDH2R140Q-IN-1 可用于研究急性髓细胞白血病

IDH2R140Q-IN-1

IDH2R140Q-IN-1 Chemical Structure

CAS No. : 2469044-23-1

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生物活性

IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].

分子量

482.42

Formula

C22H20F6N6

CAS 号

2469044-23-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491.

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