Deac-SS-Biotin

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Deac-SS-Biotin 

Deac-SS-Biotin 是一种有效的抗癌剂。Deac-SS-Biotin 通过生物素介导的内吞作用摄取进入细胞。Deac-SS-Biotin 与 DTT (谷胱甘肽) 结合可有效抑制微管组装并显示出更强的抗肿瘤活性。

Deac-SS-Biotin

Deac-SS-Biotin Chemical Structure

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生物活性

Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].

体外研究
(In Vitro)

Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin[1].
Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SGC-7901, A549, Hela, L929 cells
Concentration: 0-20 µM
Incubation Time: 72 h
Result: Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 0.17 µM
Incubation Time:
Result: Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.

分子量

763.94

Formula

C35H45N3O10S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420.

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