HE-S2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HE-S2 

HE-S2 是一种抗体偶联药物,可触发有效的抗肿瘤免疫反应。HE-S2 通过阻断 PD-1/PD-L1 的相互作用,激活 Toll 样受体 7/8 (TLR7/8) 信号通路发挥作用。HE-S2 具有显著的抗肿瘤活性。

HE-S2

HE-S2 Chemical Structure

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生物活性

HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity[1].

IC50 & Target

PD-1/PD-L1 and TLR7/8 [1]

体外研究
(In Vitro)

HE-S2 (10 ng; 30 min) effectively targets and binds with PD-L1in MC38 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

787.95

Formula

C38H45N9O6S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64(21):15716-15726.

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