Carbonic anhydrase inhibitor 5

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Carbonic anhydrase inhibitor 5 

Carbonic anhydrase inhibitor 5 是一种有效且具有选择性的的人碳酸酐酶 (hCA) 抑制剂,hCA II、hCA IX 和 hCA XII 的 IC50s 分别为42.9 nM、47.6 nM 和 6.7 nM。

Carbonic anhydrase inhibitor 5

Carbonic anhydrase inhibitor 5 Chemical Structure

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生物活性

Carbonic anhydrase inhibitor 5 is a potent and selective human carbonic anhydrase (hCA) inhibitor with IC50s of 42.9, 47,6 and 6.7 nM for hCA II, hCA IX and hCA XII, respectively[1].

IC50 & Target

IC50: 42.9 nM (hCA II), 47.6 nM (hCA IX), 6.7 nM (hCA XII)[1]

分子量

465.95

Formula

C24H20ClN3O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Swain B, et al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022;234:114247.

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