Carbonic anhydrase inhibitor 7

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Carbonic anhydrase inhibitor 7 

Carbonic anhydrase inhibitor 7 (化合物 5b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂,对 hCA IXhCA IIhCA XIIhCA IKi 值分别为 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM。

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

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生物活性

Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].

分子量

447.46

Formula

C23H17N3O5S

CAS 号

546105-61-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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