KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity^[1].

IC₅₀: 6.16 μM (KIF18A)^[1]

KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)^[1].
KIF18A-IN-4 (0-10 μM; overnight) has an EC₅₀ of 6.35 μM in OVCAR-3 cells by the mitotic index assay^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

413.53

C₂₂H₂₇N₃O₃S

1197522-21-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.