上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
MS143
MS143 是一种有效的 AKT 降解剂,在 PC3 细胞中 DC50=46 nM,GI50=0.8 µM。MS143 通过劫持泛素-蛋白酶体系统,以浓度和时间依赖性的方式诱导快速、稳定的 AKT 降解。MS143 能抑制癌细胞生长。
MS143 Chemical Structure
CAS No. : 2376137-41-4
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生物活性 |
MS143 is a potent AKT degrader (DC50=46 nM and GI50=0.8 µM in PC3 cells). MS143 induces rapid and robust AKT degradation in a concentration- and time-dependent manner via hijacking the ubiquitin-proteasome system. MS143 can suppress cancer cell growth[1]. |
IC50 & Target |
AKT |
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体外研究 (In Vitro) |
MS143 (1 nM-10 μM; 24 hours) induces T-AKT degradation with a concentration-dependent manner in PC3 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Western Blot Analysis
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体内研究 (In Vivo) |
MS143 (75 mg/kg; i.p., 22 days) drastically inhibits the tumor growth by 92%, also substantially degrades T-AKT and P-AKT, and effectively inhibits the downstream signaling (PRAS40 phosphorylation) in xenograft mice[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
1121.87 |
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Formula |
C59H81ClN12O6S |
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CAS 号 |
2376137-41-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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