TLR7/8 agonist 6

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TLR7/8 agonist 6 

TLR7/8 agonist 6 (Compound 4) 是 TLR7/8 的有效激动剂,IC50 值分别为 0.18 和 5.34 μM。TLR7/8 agonist 6 是一种咪唑喹啉衍生物化合物。Toll 样受体 (TLR) 7 和 8 是开发用于治疗传染病、癌症和自身免疫性疾病的免疫调节药物的关键靶点。

TLR7/8 agonist 6

TLR7/8 agonist 6 Chemical Structure

CAS No. : 2115702-83-3

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生物活性

TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC50s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders[1].

分子量

417.50

Formula

C24H27N5O2

CAS 号

2115702-83-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.

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