Microtubule destabilizing agent-1

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Microtubule destabilizing agent-1 

Microtubule destabilizing agent-1 (Compound 12b) 是一种基于异羟肟酸的微管去稳定剂 (MDA)。Microtubule destabilizing agent-1 显示出良好的代谢稳定性、高生物利用度和有效的抗肿瘤活性。

Microtubule destabilizing agent-1

Microtubule destabilizing agent-1 Chemical Structure

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生物活性

Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity[1].

分子量

410.47

Formula

C22H26N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):15379-15401.

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