(E/Z)-Zotiraciclib citrate(Synonyms: (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate)

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(E/Z)-Zotiraciclib citrate (Synonyms: (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate)

(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate 是一种有效的 CDK2JAK2FLT3 抑制剂,用于癌症研究。

(E/Z)-Zotiraciclib citrate(Synonyms: (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate)

(E/Z)-Zotiraciclib citrate Chemical Structure

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生物活性

(E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1].

IC50 & Target[1]

CDK2

 

JAK2

 

FLT3

 

分子量

564.59

Formula

C29H32N4O8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196.

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