GRK6-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

GRK6-IN-1 

GRK6-IN-1 (compound 18) 是 G 蛋白偶联受体激酶 6 (GRK6) 的有效抑制剂,IC50 为 120 nM。GRK6 是多发性骨髓瘤 (MM) 细胞存活所需的关键激酶。GRK6-IN-1 具有研究多发性骨髓瘤的潜力。

GRK6-IN-1

GRK6-IN-1 Chemical Structure

CAS No. : 2677786-61-5

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生物活性

GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma[1].

分子量

438.91

Formula

C22H23ClN6O2

CAS 号

2677786-61-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.

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