BRD4 D1-IN-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

BRD4 D1-IN-2 

BRD4 D1-IN-2 (compound 26) 是一种有效的选择性 BRD4 D1 抑制剂 (IC50<0.092 µM)。BRD4 D1-IN-2 对 BRD4 D1 具有 15 nM 亲和力,对 BRD2 D1 和 BRD4 D2 具有 500 倍以上的选择性。

BRD4 D1-IN-2

BRD4 D1-IN-2 Chemical Structure

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生物活性

BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC[1].

IC50 & Target[1]

BRD4 BD1

<0.092 μM (IC50)

分子量

592.70

Formula

C33H39F3N6O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Cui H, et al. A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J Med Chem. 2022;65(3):2342-2360.

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