Zaragozic acid B

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Zaragozic acid B 

Zaragozic acid B 是一种真菌代谢产物,是法尼基蛋白转移酶 (FPTase) 和角鲨烯合成酶 (squalene synthases) 的有效抑制剂。Zaragozic acid B 是一种潜在的抗癌药物。

Zaragozic acid B

Zaragozic acid B Chemical Structure

CAS No. : 146389-61-9

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生物活性

Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].

体外研究
(In Vitro)

Zaragozic acid B is a very potent inhibitor of squalene synthases from all three sources (RSS: rat liver microsome; YSS: Candida albicans; HSS: Hep G2 cells) with the IC50 values range from 0.22 to 0.67 nM[1].
Zaragozic acid B inhibits bovine FPTase (IC50=100 nM), human FPTase (IC50=185 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

730.84

Formula

C39H54O13

CAS 号

146389-61-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany • December 1995.

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