DM1-SMe

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DM1-SMe 

DM1-SMe 是 IMGN901 中 Maytansinoid 的一种非结合形式。在一组人类肿瘤细胞系中,DM1-SMe 药效大约是母体 Maytansinoid 的3-10倍,对一组癌细胞的毒性的 IC50 范围为 0.003 至 0.01 nM。

DM1-SMe

DM1-SMe Chemical Structure

CAS No. : 138148-68-2

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生物活性

DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent drug Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1].

IC50 & Target[1]

Maytansinoids

 

分子量

784.38

Formula

C36H50ClN3O10S2

CAS 号

138148-68-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867.

    [2]. Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107.

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