Talotrexin ammonium(Synonyms: PT523 ammonium)

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Talotrexin ammonium (Synonyms: PT523 ammonium)

Talotrexin ammonium 是一种非多谷氨酸抗叶酸剂。Talotrexin ammonium 通过靶向 DHFR 抑制肿瘤生长来提高广谱癌症模型的抗肿瘤活性。

Talotrexin ammonium(Synonyms: PT523 ammonium)

Talotrexin ammonium Chemical Structure

CAS No. : 678991-55-4

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生物活性

Talotrexin ammonium is a nonpolyglutamatable antifolate. Talotrexin ammonium improves antitumor activity in a broad spectrum of cancer models by targeting DHFR to inhibit tumor growth[1].

Formula

C27H27N9O6.xH3N
CAS 号

678991-55-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. C. S. Rocha Lima, et al. A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).

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