iCRT-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

iCRT-5 

iCRT-5 是一种 β-catenin 调节的转录 (CRT) 抑制剂。iCRT-5 可以阻断 Wnt/β-catenin 报告基因活性并下调 β-catenin 表达。iCRT-5 可用于多发性骨髓瘤的研究。

iCRT-5

iCRT-5 Chemical Structure

CAS No. : 18623-44-4

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生物活性

iCRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block Wnt/β-catenin reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma[1][2].

IC50 & Target

β-catenin-regulated transcription (CRT)[1]

分子量

367.44

Formula

C16H17NO5S2

CAS 号

18623-44-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Käfer R, et, al. Inhibitors of β-catenin affect the immuno-phenotype and functions of dendritic cells in an inhibitor-specific manner. Int Immunopharmacol. 2016 Mar;32:118-124.

    [2]. Narayanan BA, et, al. Antagonistic effect of small-molecule inhibitors of Wnt/β-catenin in multiple myeloma. Anticancer Res. 2012 Nov;32(11):4697-707.

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