Abemaciclib metabolite M2-d6(Synonyms: LSN2839567-d6)

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Abemaciclib metabolite M2-d6 (Synonyms: LSN2839567-d6)

Abemaciclib metabolite M2-d6 (LSN2839567-d6) 是 Abemaciclib metabolite M2 的氘代物。Abemaciclib metabolite M2 (LSN2839567) 是 Abemaciclib 的代谢物,为有效的 CDK4CDK6 抑制剂,IC50 值为 1-3 nM。具有抗肿瘤活性。

Abemaciclib metabolite M2-d6(Synonyms: LSN2839567-d6)

Abemaciclib metabolite M2-d6 Chemical Structure

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生物活性

Abemaciclib metabolite M2-d6 (LSN2839567-d6) is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

484.58

Formula

C25H22D6F2N8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).

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