Decylubiquinone(Synonyms: 癸基泛醌)

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Decylubiquinone (Synonyms: 癸基泛醌)

Decylubiquinone 是泛醌 (辅酶 Q10) 的类似物。Decylubiquinone 阻止活性氧 (ROS) 的产生以响应谷胱甘肽消耗并抑制线粒体通透性转变的激活。

Decylubiquinone(Synonyms: 癸基泛醌)

Decylubiquinone Chemical Structure

CAS No. : 55486-00-5

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生物活性

Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].

体外研究
(In Vitro)

Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced[1].
Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells)
Concentration: 10 μM
Incubation Time: 6 hours
Result: Attenuated the ROS increase in HL60 (B) cells.

分子量

322.44

Formula

C19H30O4
CAS 号

55486-00-5
中文名称

癸基泛醌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jeffrey S Armstrong, et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem. 2003 Dec 5;278(49):49079-84.

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