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EN219
EN219 是一种特异性适中的作用于 RNF114 的 N 端半胱氨酸 C8 的合成共价配体， IC50为470 nM。EN219 抑制 RNF114 介导的自身泛素化和 p21 泛素化。
EN219 Chemical Structure
CAS No. : 380351-29-1
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| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
EN219 (1 μM; 90 min) interacts with RNF114 C8, TUBB1 C201, HSPD1 C442, and HIST1H3A C97 demonstrated by isotopic tandem orthogonal proteolysisABPP (isoTOP-ABPP) analysis[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
456.56 |
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| Formula |
C17H13Br2ClN2O |
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| CAS 号 |
380351-29-1 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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