Hydrocortisone-d4(Synonyms: Cortisol-d4)

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Hydrocortisone-d4 (Synonyms: Cortisol-d4)

Hydrocortisone-d4 (Cortisol-d4) 是 Hydrocortisone 的氘代物。Hydrocortisone (Cortisol) 是肾上腺皮质分泌的类固醇激素或糖皮质激素。

Hydrocortisone-d4(Synonyms: Cortisol-d4)

Hydrocortisone-d4 Chemical Structure

CAS No. : 73565-87-4

规格 是否有货
1 mg 询价
5 mg 询价

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生物活性

Hydrocortisone-d4 (Cortisol-d4) is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

366.48

Formula

C21H26D4O5

CAS 号

73565-87-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.

    [3]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.

    [4]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

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