Cycleanine(Synonyms: 轮环藤碱)

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Cycleanine (Synonyms: 轮环藤碱) 纯度: 99.80%

Cycleanine 是一种高效的血管选择性 Ca– 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。

Cycleanine(Synonyms: 轮环藤碱)

Cycleanine Chemical Structure

CAS No. : 518-94-5

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10 mg ￥3600 In-stock
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生物活性

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

体外研究
(In Vitro)

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.

体内研究
(In Vivo)

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

622.75

Formula

C38H42N2O6
CAS 号

518-94-5
中文名称

轮环藤碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Martínez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.

    [2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.

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