PARP/EZH2-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PARP/EZH2-IN-1 

PARP/EZH2-IN-1 是一种 PARPIC50 6.87 nM)和 EZH2IC50 36.51 nM)的双特异性抑制剂,用于治疗野生型BRCA三阴性乳腺癌。

PARP/EZH2-IN-1

PARP/EZH2-IN-1 Chemical Structure

CAS No. : 2687273-52-3

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生物活性

PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

IC50 & Target

PARP-1

6.87 nM (IC50)

EZH2

36.51 nM (IC50)

分子量

768.83

Formula

C43H41FN8O5

CAS 号

2687273-52-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650.

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