Tetraethylene glycol-d8(Synonyms: PROTAC Linker 18-d8)

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Tetraethylene glycol-d8 (Synonyms: PROTAC Linker 18-d8)

Tetraethylene glycol-d8 (PROTAC Linker 18-d8) 是 Tetraethylene glycol 的氘代物。Tetraethylene glycol (PROTAC Linker 18) 是一种 PROTAC linker,属于 PEG 类。Tetraethylene glycol 可用于合成 PROTAC 分子。

Tetraethylene glycol-d8(Synonyms: PROTAC Linker 18-d8)

Tetraethylene glycol-d8 Chemical Structure

CAS No. : 2732981-70-1

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生物活性

Tetraethylene glycol-d8 (PROTAC Linker 18-d8) is the deuterium labeled Tetraethylene glycol. Tetraethylene glycol (PROTAC Linker 18) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

202.27

Formula

C8H10D8O5

CAS 号

2732981-70-1

中文名称

三缩四乙二醇 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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