Heliotrine N-oxide-d3

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Heliotrine N-oxide-d3 

Heliotrine N-oxide-d3 是 Heliotrine N-oxide 的氘代物。Heliotrine N-oxide 是 Heliotrine (HY-126128) 对应的吡咯利嗪生物碱类氮氧化物 (PA N-oxide)。Heliotrine N-oxide 可导致吡咯基 DNA 加合物 (DNA adduct) 的形成,并可能引发 PA 诱导的肝肿瘤的启动。

Heliotrine N-oxide-d3

Heliotrine N-oxide-d3 Chemical Structure

CAS No. : 2714430-96-1

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生物活性

Heliotrine N-oxide-d3 is the deuterium labeled Heliotrine N-oxide. Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

332.41

Formula

C16H24D3NO6

CAS 号

2714430-96-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Xiaobo He, et al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.

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