Carglumic Acid-d5(Synonyms: N-Carbamyl-L-glutamic acid-d5)

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Carglumic Acid-d5 (Synonyms: N-Carbamyl-L-glutamic acid-d5)

Carglumic Acid-d5 (N-Carbamyl-L-glutamic acid-d5) 是 Carglumic Acid 的氘代物。Carglumic acid (N-Carbamyl-L-glutamic acid) 是 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1 (CPS1) 的活化剂,用于研究与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症。

Carglumic Acid-d5(Synonyms: N-Carbamyl-L-glutamic acid-d5)

Carglumic Acid-d5 Chemical Structure

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生物活性

Carglumic Acid-d5 (N-Carbamyl-L-glutamic acid-d5) is the deuterium labeled Carglumic Acid. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

195.18

Formula

C6H5D5N2O5

中文名称

卡谷氨酸 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Chen CT, et al. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015 Nov 15;5(12):3560-9.

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