RR6-d5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

RR6-d5 

RR6-d5 是 RR6 的氘代物。RR6 是一种有效的,选择性的,可逆的,竞争性和具有口服活性的 vanin 抑制剂,对重组 vanin-1IC50 为 540 nM。RR6 还有效抑制人,牛和大鼠血清泛酶,IC50 值分别为 40 nM,41 nM 和 87 nM。

RR6-d5

RR6-d5 Chemical Structure

CAS No. : 2714413-24-6

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生物活性

RR6-d5 is the deuterium labeled RR6. RR6 is a potent, selective, reversible, competitive and orally active vanin inhibitor with an IC50 of 540 nM for recombinant vanin-1. RR6 also potently inhibits human, bovine and rat serum pantetheinase with IC50 values of 40 nM, 41 nM and 87 nM, respectively[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

298.39

Formula

C16H18D5NO4

CAS 号

2714413-24-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Jansen PA et al. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol. 2013 Mar 15;8(3):530-4.

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