OICR-9429-N-C2-NH2

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OICR-9429-N-C2-NH2 

OICR-9429-N-C2-NH2 是 Wd40 重复域蛋白 5 (WDR5) 的配体,可用于合成 PROTAC。详细信息请参考专利文献 WO2019246570A1 中的中间体 2。

OICR-9429-N-C2-NH2

OICR-9429-N-C2-NH2 Chemical Structure

CAS No. : 2407457-55-8

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生物活性

OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].

IC50 & Target

Ligand for Target Protein for PROTAC[1]

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

597.67

Formula

C31H38F3N7O2

CAS 号

2407457-55-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1.

    [2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

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