TC-E 5001

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TC-E 5001 

TC-E 5001 是一种 Wnt 通路抑制剂,通过新型腺苷袋结合抑制端锚聚合酶 1/2 (TNKS1/2),Kds 值分别为 79 和 28 nM。TC-E 5001 还抑制 Axin2STFIC50 值分别为 0.709 μM 和 0.215 μM。

TC-E 5001

TC-E 5001 Chemical Structure

CAS No. : 865565-29-3

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生物活性

TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].

IC50 & Target[1]

TNKS1

79 nM (Ki)

TNKS2

28 nM (Ki)

体外研究
(In Vitro)

TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

409.46

Formula

C20H19N5O3S

CAS 号

865565-29-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shultz MD, et, al. [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55(3):1127-36.

    [2]. Lien VT, et, al. Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. 2019 Jour; 9(63): 37092-37100.

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