Peptide 74

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Peptide 74  纯度: 98.07%

Peptide 74 是一种合成肽,含有基质金属蛋白酶 (MMP) 的前域序列。Peptide 74 在体外抑制活化形式的 72-kDa IV 型胶原酶。

Peptide 74

Peptide 74 Chemical Structure

CAS No. : 132116-39-3

规格 价格 是否有货 数量
5 mg ¥800 In-stock
10 mg ¥1300 In-stock
25 mg ¥2600 In-stock
50 mg   询价  
100 mg   询价  

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Peptide 74 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro[1].

体外研究
(In Vitro)

Peptide 74 (30 μM) reduces both A2058 and HT 1080 tumor cell invasion by 60-80%[1].
Peptide 74 (30 μM) shows no cytotoxic action and does not inhibit chemotaxis or affect HT1080 and A2058 human tumor cells number[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1558.79

Formula

C62H107N23O20S2

CAS 号

132116-39-3

Sequence Shortening

TMRKPRCGNPDVAN

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL (64.15 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6415 mL 3.2076 mL 6.4152 mL
5 mM 0.1283 mL 0.6415 mL 1.2830 mL
10 mM 0.0642 mL 0.3208 mL 0.6415 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. A Melchiori, et al. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6.

    [2]. P P Lee, et al. Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development. J Cell Physiol. 2001 Jul;188(1):75-88.

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