Pomalidomide-6-O-CH3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pomalidomide-6-O-CH3 

Pomalidomide-6-O-CH3 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Pomalidomide-6-O-CH3 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 Chemical Structure

CAS No. : 1547163-08-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.27

Formula

C14H13N3O5
CAS 号

1547163-08-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务