Pomalidomide-6-O-CH3

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Pomalidomide-6-O-CH3 

Pomalidomide-6-O-CH3 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体,用于募集 cereblon 蛋白。Pomalidomide-6-O-CH3 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 Chemical Structure

CAS No. : 1547163-08-5

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生物活性

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

303.27

Formula

C14H13N3O5

CAS 号

1547163-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

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