SB 258719 hydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SB 258719 hydrochloride 

SB 258719 hydrochloride 是一种选择性的 5-HT7 受体拮抗剂,与该受体亲和度高(pKi=7.5)。SB-258719 hydrochloride 可以用于癌症和神经系统疾病的研究 。

SB 258719 hydrochloride

SB 258719 hydrochloride Chemical Structure

CAS No. : 1217674-10-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

SB 258719 hydrochloride 的其他形式现货产品:

SB 258719

生物活性

SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases[1][2].

IC50 & Target[1]

5-HT7 Receptor

7.5 (pKi)

体外研究
(In Vitro)

SB-258719 (1, 3 and 10 μM; HEK 293 cells) hydrochloride produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SB-258719 (5~20 mg/kg; i.p.) hydrochloride significantly attenuates the 5-CT-induced hypothermia[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (20~25 g)[2].
Dosage: 5~20 mg/kg
Administration: I.p.
Result: Significantly attenuated the 5-CT-induced hypothermia.

分子量

374.97

Formula

C18H31ClN2O2S

CAS 号

1217674-10-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br J Pharmacol. 1998;124(6):1300-1306.

    [2]. Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037.

    [3]. Fatima S, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10(2):195-212.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务