CDK4/6-IN-6

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CDK4/6-IN-6 

CDK4/6-IN-6 (example A94) 是一种有效的 CDK4/CDK6 抑制剂,对CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值为 0.6 nM 和 13.9 nM。

CDK4/6-IN-6

CDK4/6-IN-6 Chemical Structure

CAS No. : 2380321-51-5

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生物活性

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].

IC50 & Target[1]

Cdk4/cyclin D1

0.6 nM (Ki)

cdk6/cyclin D3

13.9 nM (Ki)

体外研究
(In Vitro)

CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

463.93

Formula

C22H27ClFN5O3

CAS 号

2380321-51-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

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