CDK4/6-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK4/6-IN-5 

CDK4/6-IN-5 是一种有效的 CDK4CDK6 抑制剂,对 CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值为 0.2 和 4.4 nM。

CDK4/6-IN-5

CDK4/6-IN-5 Chemical Structure

CAS No. : 2380321-50-4

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生物活性

CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).

体外研究
(In Vitro)

The CDK4 and CDK6 cell-based IC50s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

527.01

Formula

C22H28ClFN6O4S

CAS 号

2380321-50-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

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