Simotinib hydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Simotinib hydrochloride 

Simotinib hydrochloride 是一种选择性、特异性、口服生物利用度高的 EGFR 酪氨酸激酶抑制剂,IC50 为 19.9 nM。抗肿瘤活性.。

Simotinib hydrochloride

Simotinib hydrochloride Chemical Structure

CAS No. : 1538617-88-7

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Simotinib hydrochloride 的其他形式现货产品:

Simotinib

生物活性

Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].

IC50 & Target

EGFR

19.9 nM (pIC50)

体外研究
(In Vitro)

Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

537.41

Formula

C25H27Cl2FN4O4

CAS 号

1538617-88-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hu XS, et al. Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non-small cell lung cancer: results of a phase Ib trial. Cancer Manag Res. 2019;11:4449-4459. Published 2019 May 13.

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