Trabectedin D3(Synonyms: Ecteinascidin 743 D3; ET-743 D3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Trabectedin D3 (Synonyms: Ecteinascidin 743 D3; ET-743 D3)

Trabectedin D3 (Ecteinascidin 743 D3) 是 Trabectedin 的氘代物。Trabectedin (Ecteinascidin 743; ET-743) 是一种四氢异喹啉生物碱,具有有效的抗肿瘤活性。Trabectedin 与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡 (apoptosis),并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 可用于软组织肉瘤和卵巢癌的研究。

Trabectedin D3(Synonyms: Ecteinascidin 743 D3;  ET-743 D3)

Trabectedin D3 Chemical Structure

规格 是否有货
1 mg 询价
2 mg 询价
5 mg 询价

* Please select Quantity before adding items.

生物活性

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment[1][2][3].

分子量

764.86

Formula

C39H40D3N3O11S

中文名称

他比特啶 D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.

    [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.

    [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务