Promegestone(Synonyms: 普美孕酮; R-5020; Surgestone)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Promegestone (Synonyms: 普美孕酮; R-5020; Surgestone)

Promegestone (R-5020) 是一种孕激素,是一种有效的孕酮受体 (PR) 激动剂。Promegestone 具有内分泌调节和癌症研究的潜力。

Promegestone(Synonyms: 普美孕酮; R-5020;  Surgestone)

Promegestone Chemical Structure

CAS No. : 34184-77-5

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生物活性

Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].

体外研究
(In Vitro)

Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50 of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM)[1].
Promegestone is inactive in HELN cells that express luciferase but no functional receptor[1].
Promegestone (10 nM) robustly stimulates SLC37A2 expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.47

Formula

C22H30O2

CAS 号

34184-77-5

中文名称

普美孕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Clémentine Garoche, et al. Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins. Environ Sci Technol. 2020 Aug 4;54(15):9510-9518.

    [2]. Michael A Kirby, et al. Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reprod Sci. 2016 Nov;23(11):1473-1483.

    [3]. Todd P Knutson, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10(1):89.

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