Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
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Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax). A549 cells 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.