Norswertianin

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Norswertianin 

Norswertianin 是一种氧杂蒽酮类化合物,是一种有效的抗神经胶质瘤化合物 (anti-glioma compound)。Norswertianin 通过氧化应激和 Akt/mTOR 依赖的自噬诱导 GBM 细胞分化。

Norswertianin

Norswertianin Chemical Structure

CAS No. : 22172-15-2

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生物活性

Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy[1].

体外研究
(In Vitro)

Norswertianin (12.5-50 µM; 48 hours) stimulats expression of GFAP and β-tubulin in U251 cells[1].
Norswertianin (40 µM; 48 hours) causes the appearance of elongated processes in U251 cells, associated with G2/M cell cycle arrest[1].
Norswertianin (40 µM; 48 hours) exhibits an increase in intracellular acidification and LC3 conversion[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

260.20

Formula

C13H8O6

CAS 号

22172-15-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gordana Tovilovic-Kovacevic, et al. Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line. Phytomedicine

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