Lasiocarpine

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Lasiocarpine 

Lasiocarpine 是一种有肝毒性吡咯里西定生物碱 ( hepatotoxic PA),在体内可引起致命的肝静脉闭塞性疾病。Lasiocarpine 只有在代谢转化为毒性中间体后才有毒性,包括 Dehydrolasiocarpine 和 N-oxide。

Lasiocarpine

Lasiocarpine Chemical Structure

CAS No. : 303-34-4

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生物活性

Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1].

体外研究
(In Vitro)

Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1].
Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1].
Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

411.49

Formula

C21H33NO7

CAS 号

303-34-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Muluneh M Fashe, et al. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine. Chem Res Toxicol. 2015 Oct 19;28(10):2034-44.

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