Gastrazole(Synonyms: JB95008)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Gastrazole (Synonyms: JB95008)

Gastrazole (JB95008) 是一种有效的和选择性的 CCK2/gastrin 受体拮抗剂。Gastrazole 可降低胃酸水平。Gastrazole 抑制胃泌素刺激的胰腺癌生长。

Gastrazole(Synonyms: JB95008)

Gastrazole Chemical Structure

CAS No. : 862583-15-1

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生物活性

Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2].

IC50 & Target

CCK2/gastrin receptor[1]

体内研究
(In Vivo)

Gastrazole (0.15-3 μmol/kg; i.v.) dose-dependently inhibits the Pentagastrin-stimulated gastric acid secretion[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with a gastric fistula[2]
Dosage: 0.15, 0.3, 3 mg/kg
Administration: Intravenous administration
Result: Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%.

分子量

687.63

Formula

C34H32FN5Na2O7

CAS 号

862583-15-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chau I, et, al. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15.

    [2]. Rudholm T, et, al. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009 Jan 8;152(1-3):8-12.

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