Migrastatin

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Migrastatin 

Migrastatin 是一种典型的 Fascin1 抑制剂。Migrastatin 是从链霉菌属 MK929-43F1 的培养液中分离出来的。Migrastatin 抑制肿瘤细胞迁移。

Migrastatin

Migrastatin Chemical Structure

CAS No. : 314245-65-3

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生物活性

Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2].

IC50 & Target

Fascin1[1]

体外研究
(In Vitro)

Migrastatin (100 μM) leads to the disorganization of the bundles. Migrastatin (100 μM; HCT-116 and DLD-1 cells) prevents cell migration[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

489.60

Formula

C27H39NO7

CAS 号

314245-65-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Montoro-García S, et al. Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. J Mol Med (Berl). 2020;98(3):383-394.

    [2]. Nakae K, et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000;53(10):1130-1136.

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