CGP78850

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CGP78850 

CGP78850 是 Grb2 SH2-phosphopeptide 相互作用的有力和选择性竞争者。CGP78850可用于癌症研究。

CGP78850

CGP78850 Chemical Structure

CAS No. : 258326-83-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

IC50 & Target

Grb2 SH2-phosphopeptide[1]

体外研究
(In Vitro)

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0~100 μM
Incubation Time: 90 minutes
Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.

分子量

723.75

Formula

C36H46N5O9P

CAS 号

258326-83-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

发表评论