Antitumor agent-28

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Antitumor agent-28 

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

Antitumor agent-28

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

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生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

512.62

Formula

C25H32N6O4S

CAS 号

2097499-67-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

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